Horizon Particle Analyzer

Labs' HORIZON system uses background membrane imaging (BMI)
technology to measure and characterize subvisible particles in
a high-throughput, low-volume format.
BMI has its roots in membrane microscopy
- a USP-cleared lot-release method that images particles
on a membrane surface. The fully automated,
liquid-free HORIZON system uses disposable membrane plates
and automated image processing to quickly generate reliable
and accurate particle counts and sizes.
It can perform particle characterization in up to 96 samples
in a single run, using only 25 µL per sample.
BMI is also insensitive to the refractive index of the solution,
allowing for reliable measurement of translucent protein aggregates.
The HORIZON system uses sophisticated image processing techniques to analyze images and acquire particle data.
The key is to first create a background image
of the membrane. After the samples are filtered through
a vacuum and the particles are captured,
the same membrane with the sample particles
on the surface is re-imaged.
The sample image is precisely aligned
with the background image and then processed pixel
by pixel so that the background structure is eliminated
and the particles can be viewed in high contrast.